Yes; people who are identified as being at risk for HBV infection during pregnancy should be vaccinated. They also should be counseled concerning other methods to prevent HBV infection. Providers should administer an age-appropriate 3-dose series of Twinrix, Engerix-B or Recombivax HB.
Until safety data are available for Heplisav-B or PreHevbrio administration during pregnancy, ACIP does not recommend the use of either of these products to vaccinate during pregnancy. Pregnancy testing prior to administration of these products is not recommended.