RSVPreF3 (Arexvy, GSK) is supplied as a single-dose vial of lyophilized antigen component (powder) and a single-dose vial of adjuvant suspension component (liquid). Both the liquid and the powder should be stored refrigerated between 2°C and 8°C (36°F and 46°F) in the original package in order to protect vials from light. Do not freeze. Discard if either component has been frozen. After reconstitution, administer immediately or store in the refrigerator between 2°C and 8°C (36°F to 46°F) or at room temperature (defined for this vaccine as up to 25°C [77°F]) for up to 4 hours before use. Discard reconstituted vaccine if not used within 4 hours.
RSVpreF (Abrysvo, Pfizer) is supplied in a kit that includes a vial of lyophilized antigen component (a white powder), a prefilled syringe with a sterile water diluent, and a vial adapter. Store at refrigerated temperatures between 2°C and 8°C (36°F and 46°F) in the original carton. Do not freeze. Discard if frozen. Follow reconstitution guidelines at www.fda.gov/media/168889/download. After reconstitution, administer immediately or store at room temperature (defined for this vaccine as 15ºC to 30ºC [59ºF to 86ºF]) for up to 4 hours. Do not store reconstituted Abrysvo vaccine in the refrigerator or freezer. Discard reconstituted vaccine if not used within 4 hours.
Last reviewed:
January 22, 2024
Nirsevimab comes in two single-dose manufacturer-filled syringe (MFS) formulations: 50-mg and 100-mg. Nirsevimab should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). It may be kept at room temperature 68°F to 77°F (20°C to 25°C) for a maximum of 8 hours. After removal from the refrigerator, nirsevimab must be used within 8 hours or discarded. Store nirsevimab in the original carton to protect it from light until time of use. Do not freeze. Do not shake. Do not expose to heat.
Last reviewed:
January 22, 2024
No. Seasonal influenza vaccines are reformulated each year; for this reason, all unused seasonal influenza vaccines expire and should be discarded no later than the end of June each season. RSV products (vaccines and preventive antibody) do not change each season and products in your storage unit now may not expire until sometime during or after the next season.
Unless public health authorities advise otherwise, RSV vaccine should not be given during pregnancy after January. Likewise, nirsevimab should not be given to infants after March or before October (unless specifically instructed by public health authorities). Recommendations for timing of RSV vaccination of adults age 60 or older is less precisely defined because vaccination is expected to protect the recipient through two season; however, demand is likely to be lower in spring and summer months. Properly store and clearly label unexpired products remaining in your storage unit during periods when they are not in use and train staff on the timing of these products. Consider storage and labeling that minimizes the risk of mishandling or administration outside the times when the product is recommended to be used.
Last reviewed:
January 22, 2024
