Hib vaccination is contraindicated for individuals known to have experienced a severe allergic reaction (anaphylaxis) to a vaccine component or following a prior dose. Hib-containing vaccines are contraindicated for children younger than 6 weeks of age because of the potential for development of immunologic tolerance. The PedvaxHIB vial stopper contains dry natural rubber which could produce an allergic reaction in children with severe allergy to latex.
Vaccination should be delayed for children with moderate or severe acute illnesses. Minor illnesses, such as a mild upper respiratory infection are not a reason to delay vaccination.
Contraindications and precautions for the use of Pentacel (DTaP-IPV/Hib) and Vaxelis (DTaP-Hib-HepB-IPV) are the same as those for their individual component vaccines.