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  • COVID-19
  • Contraindications & Precautions

Can people who are immunocompromised or who have autoimmune disease be vaccinated with COVID-19 vaccines?

Yes, they may be vaccinated with any FDA-licensed or FDA-authorized updated (2023–2024 Formula) COVID-19 vaccine (Moderna, Pfizer, or Novavax) as long as they do not have a contraindication to vaccination. Antibody testing is not recommended to assess for immunity to SARS-CoV-2 following COVID-19 vaccination.

Recipients should be counseled about the unknown and variable effectiveness of COVID-19 vaccination in immunocompromised populations and the potential for reduced immune responses. They should maintain other practices, such as wearing a mask in public and avoiding crowds, to reduce their risk of exposure to SARS-CoV-2.

The current immunization schedules for each available vaccine product for people age 6 months or older with moderate or severe immunocompromise are shown on CDC’s Interim COVID-19 Immunization Schedule for Persons 6 Months of Age and Older:

CDC has also developed an infographic for use with patients who have moderate to severe immunocompromise when determining what updated (2023–2024 Formula) COVID-19 vaccine is due based on the individual’s age and past COVID-19 vaccination history:

CDC provides detailed considerations for vaccination of people with moderate or severe immunocompromise here:

Last reviewed: October 26, 2023

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