• COVID-19
  • Contraindications & Precautions

Can people who are immunocompromised or who have autoimmune disease be vaccinated with COVID-19 vaccines?

Yes, they may be vaccinated with any FDA-licensed or FDA-authorized updated (2023–2024 Formula) COVID-19 vaccine (Moderna, Pfizer, or Novavax) as long as they do not have a contraindication to vaccination. Antibody testing is not recommended to assess for immunity to SARS-CoV-2 following COVID-19 vaccination.

Recipients should be counseled about the unknown and variable effectiveness of COVID-19 vaccination in immunocompromised populations and the potential for reduced immune responses. They may consider other practices to reduce their risk of infection. CDC has published additional information about respiratory virus prevention for people with weakened immune systems: www.cdc.gov/respiratory-viruses/risk-factors/weakened-immune-systems.html.

CDC has developed an infographic for use with patients who have moderate to severe immunocompromise when determining what updated (2023–2024 Formula) COVID-19 vaccine is due based on the individual’s age and past COVID-19 vaccination history: www.cdc.gov/vaccines/covid-19/downloads/COVID19-vaccination-recommendations-immunocompromised.pdf.

CDC provides detailed considerations for vaccination of people with moderate or severe immunocompromise here: www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html#immunocompromised.

Last reviewed: March 19, 2024

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