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  • Pneumococcal
  • Adults who have had PCV13

Which adults ages 19–64 years should receive a second dose of PPSV23 before age 65?

A second PPSV23 given 5 years after the first dose is recommended for people age 19 through 64 years who were vaccinated with PCV13 and PPSV23 and who have one of the following:

  • functional or anatomic asplenia (including persons with sickle cell disease or splenectomy patients)
  • chronic renal failure (including dialysis patients) or nephrotic syndrome
  • immunocompromise (including HIV infection)
  • leukemia, lymphoma, Hodgkin disease, multiple myeloma, generalized malignancy
  • immunosuppressive therapy (including long-term systemic corticosteroids or radiation therapy)
  • solid organ transplant
Last reviewed: July 26, 2022

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