- Influenza
- Contraindications & Precautions
What are the contraindications and precautions for people with a history of a severe allergic reaction to a previous influenza vaccination?
A severe allergic reaction to any influenza vaccine is a contraindication to receiving additional doses of the same vaccine or receiving any egg-based influenza vaccines. The following table summarizes the contraindications and precautions for different types of influenza vaccine and has been adapted from table 3 of the 2022-23 influenza ACIP recommendations at www.cdc.gov/mmwr/volumes/71/rr/pdfs/rr7101a1-H.pdf. No changes to this general guidance were made for 2024-25 influenza season products.
Vaccine (of any valency) associated with previous serious or anaphylactic reaction | Available 2024-25 influenza vaccines | ||
Egg-based IIVs and LAIV |
Cell-culture- based IIV: ccIIV (Flucelvax) | Recombinant IIV: RIV (Flublok) | |
Any egg-based IIV or LAIV | Contraindication | Precaution † | Precaution † |
Any ccIIV | Contraindication | Contraindication | Precaution † |
Any RIV | Contraindication | Precaution † | Contraindication |
Unknown influenza vaccine | Allergist consultation recommended |
† Note regarding patients having either of the above precautions for either ccIIV or IIV: use of ccIIV and RIV in such instances should occur in an inpatient or outpatient medical setting under the supervision of a healthcare provider (HCP) who can recognize and manage severe allergic reaction; HCPs can also consider consulting with an allergist to help identify the vaccine component responsible for the reaction.