• Combination Vaccines
  • HepA-HepB (Twinrix, GSK)

We’re thinking of using Twinrix (HepA-HepB) and we’re wondering whether we can use it for doses #1 and #3 only and use single antigen hepatitis B vaccine for dose #2?

No. Twinrix contains 50% less hepatitis A antigen component than Havrix, GSK’s monovalent HepA vaccine [720 vs. 1440 EL.U.], so the patient would not receive the recommended dose of HepA vaccine antigen.

Last reviewed: July 15, 2023

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