• COVID-19
  • Contraindications & Precautions

Patients concerned about the risk of allergic reaction or side effects following COVID-19 vaccination are asking if they should take acetaminophen, aspirin, and/or antihistamines before receiving COVID-19 vaccination. What does CDC advise?

Medications to reduce fever and pain (e.g., acetaminophen, non-steroidal anti-inflammatory drugs) may be taken to treat post-vaccination local or systemic symptoms, if medically appropriate. However, routine administration of such medications before vaccination is not recommended because information on the potential impact of such use on COVID-19 vaccine-induced antibody responses is not available at this time.

Administration of antihistamines before COVID-19 vaccination to prevent allergic reactions is not recommended. Antihistamines do not prevent anaphylaxis, and their use might mask cutaneous symptoms, which could delay diagnosis and management of anaphylaxis.

Last reviewed: March 19, 2024

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