- Pneumococcal
- Recommendations for Adults
If a vaccination provider stocks only PPSV23, what should that provider do for adults now recommended to receive either PCV20 alone or PCV15 followed by PPSV23?
Studies have shown that administering a pneumococcal conjugate vaccine first leads to a better immune response to serotypes common to both vaccines when the polysaccharide vaccine (PPSV23) is given at a later date. For this reason, the Advisory Committee on Immunization Practices (ACIP) recommends that pneumococcal vaccine-naive adults receive pneumococcal conjugate vaccines either alone (PCV20) or first in a sequence (PCV15 first, followed by PPSV23). A provider who stocks only PPSV23 should consider referring such patients elsewhere to receive a conjugate vaccine, if feasible. A patient due for a conjugate vaccine who receives PPSV23 first may receive either the PCV15 or PCV20 vaccine at least one year later.