• Pneumococcal
  • Recommendations for Adults

If a vaccination provider stocks only PPSV23, what should that provider do for adults now recommended to receive either PCV20 alone or PCV15 followed by PPSV23?

Studies have shown that administering a pneumococcal conjugate vaccine first leads to a better immune response to serotypes common to both vaccines when the polysaccharide vaccine (PPSV23) is given at a later date. For this reason, CDC recommends that pneumococcal vaccine-naive adults receive pneumococcal conjugate vaccines either alone (PCV20) or first in a sequence (PCV15 first, followed by PPSV23). A provider who stocks only PPSV23 should consider purchasing a recommended pneumococcal conjugate vaccine or referring such patients elsewhere to receive a conjugate vaccine, if feasible. A patient due for a conjugate vaccine who receives PPSV23 first may receive either the PCV15 or PCV20 vaccine at least one year later.

Last reviewed: April 5, 2024

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