If a patient received Trumenba meningococcal B vaccine (MenB-FHbp) 2 months ago and Bexsero meningococcal B vaccine (MenB-4C) yesterday, should they complete the series with Trumenba or with Bexsero since the two brands are not interchangeable? What would be the intervals from the Bexsero dose to the subsequent dose(s)?

The patient can complete the series with either vaccine. If Bexsero (MenB-4C) is chosen, the second and final dose should be administered at least 1 month after yesterday’s dose. If Trumenba (MenB-FHbp) is chosen and the patient is healthy (i.e., does not have a high-risk condition for meningococcal B disease such as asplenia), the second and final dose of Trumenba should be administered at least 4 months after yesterday’s Bexsero dose (6 months after the first Trumenba dose). If the person is at increased risk for meningococcal B disease and Trumenba is being used, a second Trumenba dose should be administered 1 month after yesterday’s Bexsero dose and a third dose should be administered 4 months after the second Trumenba dose.