• Cholera
  • Travel Vaccines

Does live oral cholera vaccine CVD 103-HgR (Vaxchora, Emergent BioSolutions) need to be administered at an interval from other live oral or injectable vaccines?

With one exception, you do not need to consider the timing of this vaccine relative to other vaccines. According to CDC’s “General Best Practice Guidelines for Immunization”, concerns about spacing between doses of live vaccines not given at the same visit applies only to live injectable or intranasal vaccines. The one exception is administration of Ty21a oral typhoid vaccine and oral cholera vaccine. The CVD 103-HgR buffer might interfere with the enteric-coated Ty21a formulation. For this reason, ACIP recommends that the cholera vaccine should be administered at least 8 hours before ingesting the first dose of Ty21a vaccine.

Last reviewed: August 21, 2023

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