A child in my practice was given hepatitis A IG (GamaSTAN, Grifols) when she was 10 months old after her mother tested positive for hepatitis A. She’s scheduled for her 12-month-old well-child visit. Will this affect her vaccination schedule?

Yes. IG may be given any time before or after inactivated vaccines like HepA. However, the antibodies in IG may interfere with the effectiveness of certain live-virus vaccines, such as measles, mumps, and rubella (MMR) and varicella vaccines. CDC recommends waiting at least 6 months from the date of IG administration before administering MMR and varicella vaccines.