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Precautions and Contraindications

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Precautions and Contraindications

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Precautions and Contraindications
Do we need to check vital signs before giving vaccines?
No. ACIP does not recommend routinely checking a patient's temperature or other vital signs before vaccination. Requiring these extra steps can be a barrier to immunization.
We frequently see patients who are febrile or have an acute illness and are due for vaccinations. We are uncertain if we should withhold the vaccines or not. What do you advise?
A "moderate or severe acute illness" is a precaution for administering any vaccine. A mild acute illness (e.g., diarrhea or mild upper-respiratory tract infection) with or without fever is not a precaution, and vaccines may be given. The concern in vaccinating someone with moderate or severe illness is that a fever following the vaccine could complicate management of the concurrent illness - it could be difficult to determine if the fever was from the vaccine or due to the concurrent illness. In deciding whether to vaccinate a patient with moderate or severe illness, the clinician needs to determine if deferring vaccination will increase the patient's risk of vaccine-preventable diseases, as is the case if the patient is unlikely to return for vaccination or to seek vaccination elsewhere.
Should you administer vaccine to a child who is taking antibiotics?
Treatment with antibiotics is not a valid reason to defer vaccination. If the child or adult is otherwise well, or has only a minor illness, vaccines should be administered. But if the person has a moderate or severe acute illness (regardless of antibiotic use) vaccination may be deferred until the person's condition has improved.
Should I vaccinate a child who has recently been exposed to an infectious disease? What about a child who is convalescing from illness?
Neither of these situations is a contraindication or precaution to vaccination.
Is it necessary to routinely obtain a pregnancy test before administering any vaccines to young women?
No. Pregnancy tests prior to vaccination are not routinely recommended. However, females of childbearing age should be asked about the possibility of their being pregnant prior to being given any vaccine for which pregnancy is a contraindication or precaution. The patient's answer should be documented in the medical record. If the patient is uncertain if she is pregnant, a test should be performed before administering live virus vaccines (measles-mumps-rubella, varicella, live attenuated influenza, yellow fever).
Which vaccines are recommended to be given postpartum to mothers of newborns before hospital discharge?
The following vaccines are recommended for new mothers before they leave the hospital: (1) women without documentation of previous Tdap vaccination need a dose to protect themselves and their newborn; (2) women who did not receive influenza vaccination during pregnancy need to be vaccinated if it is still influenza vaccination season (October through March); (3) women who tested susceptible to rubella on prenatal testing need MMR vaccine even if they have 1 or 2 documented doses of MMR in their medical record; (4) women who are not immune to chickenpox need 2 doses of varicella vaccine the first dose before hospital discharge and the second dose 4 to 8 weeks after the first dose.
Is it acceptable practice to administer MMR, Tdap, and influenza vaccines to a postpartum mom who received RhoGam after delivery?
Yes. Receipt of RhoGam is not a reason to delay vaccination. See the ACIP General Recommendations on Immunization at www.cdc.gov/mmwr/pdf/rr/rr6002.pdf, page 9.
For how long should a woman of child-bearing age avoid pregnancy after receiving a live attenuated vaccine?
Due to theoretical risk to the developing fetus, ACIP recommends that women avoid pregnancy for four weeks after receiving a live attenuated vaccine (MMR, varicella, live attenuated influenza, yellow fever). This interval may be shorter than that recommended by the manufacturer.
Which vaccines are contraindicated if a child's mother or other household member is pregnant?
Having a pregnant woman in a household, including the child's mother, is not a contraindication to administration of any routinely recommended vaccine.
Which vaccines can be given to breastfeeding women?
All vaccines except smallpox can be given to breastfeeding women. Breastfeeding is a precaution for yellow fever vaccine. Women who are breastfeeding should be advised to postpone travel to yellow fever endemic or epidemic regions; however, if travel cannot be postponed, the woman should receive yellow fever vaccine.
Is there a risk for a pregnant staff person administering live-virus vaccines?
A pregnant woman may administer any vaccine except smallpox vaccine.
What percentage of vaccine recipients will experience an anaphylactic reaction?
It is estimated that for every million doses administered, about one (~0.0001%) will result in an anaphylactic reaction following vaccination. With proper screening, most providers who administer thousands of vaccines in their lifetimes will never see an anaphylactic reaction.
For which vaccines is an egg allergy a contraindication?
1) Yellow fever is contraindicated for people who have a history of a severe (anaphylactic) allergy to eggs.
2) People who have experienced a serious systemic or anaphylactic reaction (e.g., hives, swelling of the lips or tongue, acute respiratory distress, or collapse) after eating eggs should consult a specialist for appropriate evaluation to help determine if influenza vaccine should be administered. A previous severe allergic reaction to influenza vaccine, regardless of the component suspected to be responsible for the reaction, is a contraindication to future receipt of the vaccine.
People who have documented immunoglobulin E (IgE)-mediated allergy to eggs, including those who have had occupational asthma or other allergic responses to egg protein, might also be at increased risk for allergic reactions to influenza vaccine. Protocols have been published for safely administering influenza vaccine to people with egg allergies. Some people who report allergy to egg might not be egg allergic. If a person can eat lightly cooked eggs (e.g., scrambled eggs), they are unlikely to have an egg allergy. However, people who can tolerate egg in baked products (e.g., cake) might still have an egg allergy. If the person develops hives only after ingesting eggs, CDC recommends (1) they receive IIV (not LAIV), (2) the vaccine be administered by a healthcare provider familiar with the potential manifestations of egg allergy, and (3) the vaccine recipient be observed for at least 30 minutes after receipt of the vaccine for signs of a reaction.
If someone has a severe allergy to eggs with symptoms suggestive of anaphylaxis and is age 18 through 49 years, the provider can consider using Flublok, a recombinant influenza vaccine that is egg-free. Unlike current production methods for other available seasonal influenza vaccines, production of Flublok does not use the whole influenza virus or chicken eggs in its manufacturing process. If Flublok is not available or the patient is not age-eligible, then the patient should be referred to a provider experienced in managing allergy. Additional information about Flublok is available at www.cdc.gov/flu/protect/vaccine/qa_flublok-vaccine.htm.
For more details about giving influenza vaccine to people with a history of egg allergy, see the current ACIP recommendations on influenza vaccine, available at www.cdc.gov/vaccines/hcp/acip-recs/index.html. You may also find the IAC handout "Influenza Vaccination of People with a History of Egg Allergy" helpful (see www.immunize.org/catg.d/p3094.pdf).
Is egg allergy a contraindication for MMR?
Allergy to egg is not a contraindication for MMR vaccine. Although measles and mumps vaccines are grown in chick embryo tissue culture, several studies have documented the safety of these vaccines in children with severe egg allergy.
What should we ask a patient when screening to determine a gelatin allergy?
Begin by asking a general question about whether the person has an allergy to any food, medication, or vaccine. If they report an allergy to gelatin or foods that contain gelatin, you could follow up by asking if they can eat Jell-O and gelatin-type products. Gelatin allergies are extremely rare. Only severe, life-threatening (anaphylactic) allergy is a contraindication to vaccination.
Is peanut allergy a contraindication to any vaccine?
No. Vaccines available in the United States do not contain peanut products.
What is a latex allergy and why should we be concerned?
Latex is a product of the rubber tree. It is processed and used in various products, including some that come in contact with vaccines. Latex may be present in syringe plungers, vial stoppers, or in the tip caps on prefilled syringes. Some people develop sensitivity to latex, particularly if they have had significant cumulative latex exposure, such as from repeated surgeries early in life or employment in the healthcare industry. The most common type of latex sensitivity is contact-type allergy; however, on rare occasions, severe (anaphylactic) allergy occurs. People with a history of anaphylactic reactions to latex should generally not be given vaccines that have been in contact with natural rubber or latex, either in the vial or in the syringe, unless the benefit of vaccination outweighs the risk of a potential allergic reaction. People with latex allergies that are not anaphylactic in nature may be vaccinated as usual.
Do any or all vial stoppers still contain latex?
Not all stoppers in vaccine vials contain latex. Some manufacturers have switched to synthetic rubber-like materials that do not contain rubber latex or dry natural rubber. The best approach is to check the package insert, which will indicate if the packaging contains latex. Also, remember that prefilled syringes could contain natural rubber in the plunger, in the needle cover, or in the tip cap. This information is also supplied in the package insert.
Which vaccines are supplied in vials or syringes containing latex?
You can find information on latex in vaccine packaging in Appendix B of CDC's Epidemiology and Prevention of Vaccine-Preventable Diseases (the "Pink Book") at www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/latex-table.pdf.
If we have a patient who has a severe latex allergy, why shouldn't we just remove the stopper from the vial before withdrawing the vaccine in order to prevent a latex reaction?
It is not recommended to remove the stopper from a vaccine vial before administering a vaccine to a person who has a severe life-threatening allergy to latex. The vaccine has already been exposed to the rubber stopper in the vial, which might be enough of an exposure to cause a reaction. These people should not be given the vaccine.
We usually instruct our patients that they should separate vaccinations and allergy shots by at least 24 hours because if there were a reaction to one or the other, it wouldn't be possible to determine which was the cause. This becomes problematic during influenza vaccination season. What should we do?
The probability of a serious allergic reaction following any vaccine is extremely low if the person is properly screened. ACIP has not issued a recommendation that desensitization injections and vaccines be separated by any specific time period; consequently, we feel that you should take the opportunity to vaccinate.
Is there any reason to delay or adjust the immunization schedule for children with Down syndrome?
No. Children with Down syndrome should receive all indicated vaccines on the recommended schedule. These children are often at greater risk for complications from vaccine-preventable diseases than are children without Down syndrome.
Should vaccines be withheld for patients on steroids?
Steroid treatment, and possible immunosuppression, is primarily a concern with live virus vaccines. Steroid therapy that is short term (less than 2 weeks); alternate-day; physiologic replacement; topical (skin or eyes); aerosol; or given by intra-articular, bursal, or tendon injection are not considered contraindications to the use of live virus vaccines. The immunosuppressive effects of corticosteroid treatment vary, but many clinicians consider a dose equivalent to either 2 mg/kg of body weight or a total of 20 mg per day of prednisone (or equivalent) for 2 or more weeks as sufficiently immunosuppressive to raise concern about the safety of vaccination with live virus vaccines (MMR, varicella, live attenuated influenza, yellow fever). Providers should wait at least 1 month after discontinuation of therapy or reduction of dose before administering a live virus vaccine to patients who have received high systemically absorbed doses of corticosteroids for 2 weeks or more. Inactivated vaccines and toxoids can be administered to all immunocompromised patients in usual doses and schedules, although the response to these vaccines may be suboptimal.
Do people who received chemotherapy need their vaccines repeated?
Vaccines received before starting chemotherapy do not need to be repeated after chemotherapy is completed. Chemotherapy does not negate vaccine-induced immunity. However, revaccination is recommended for people who are recipients of a hematopoietic cell transplant (HCT), such as a bone marrow transplant, because immunity present before the transplant is lost and may not be replaced by donor cells.
Which vaccinations should be given to a patient who is a recipient of hematopoietic cell transplantation (HCT)?
Antibody titers to vaccine-preventable diseases decline during the 1-4 years after HCT, if the recipient is not revaccinated. HCT recipients are at increased risk for certain vaccine-preventable diseases, including those caused by encapsulated bacteria. In short, all HCT recipients should begin revaccination with inactivated vaccines 6 months after HCT. Three doses of pneumococcal conjugate vaccine (PCV) should be given 6 months following transplant followed by a dose of pneumococcal polysaccharide vaccine (PPSV) at least 8 weeks later. HCT recipients should receive 3 doses of Hib vaccine starting 6 to 12 months after successful transplant, regardless of vaccination history; doses should be administered at least 4 weeks apart. Immunocompetent people should receive MMR vaccine 24 months after transplant. For a complete discussion of the indications and schedule of vaccination, refer to CDCs web site at www.cdc.gov/vaccines/pubs/hemato-cell-transplts.htm.
What vaccines can a child with severe combined immunodeficiency disease (SCID) receive?
Children with SCID may be given inactivated vaccines (e.g., DTaP, Hib, hepatitis B, pneumococcal conjugate, hepatitis A, IPV, and injectable influenza,). They should not be given live virus vaccines (e.g., live attenuated influenza, MMR, rotavirus, and varicella).
 
This page was reviewed on May 1, 2014
Immunization Action Coalition  •  Saint Paul, MN
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This website is supported in part by a cooperative agreement from the National Center for Immunization and Respiratory Diseases (Grant No. 5U38IP000290) at the Centers for Disease Control and Prevention (CDC) in Atlanta, GA. The website content is the sole responsibility of IAC and does not necessarily represent the official views of CDC.