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Experts from the CDC Answer Questions About Vaccines

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From the National Center for Immunization and Respiratory Diseases at CDC, introducing
Medical Officer Andrew T. Kroger, MD, MPH
Nurse Educator Donna L. Weaver, RN, MN
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QUESTION: We have a 10-year-old getting renal dialysis. The nephrologist will be starting her on a monoclonal antibody that interferes with C5 complement. If we administer a MCV4 and a PPSV23 now, and then give her a PCV13 in 8 weeks, will the PCV13 interfere with the efficacy of the PPSV23 or the MCV4?
ANSWER: Recommendations to separate MCV4 and PCV13 only apply to persons with functional or anatomic asplenia. So the best schedule is to give MCV4 (either MCV4-D or MCV4-CRM) simultaneously with PCV13, and then PPSV23 in eight weeks. ACIP recommends giving PCV13 before PPSV23 in order to maximize the immune response from PCV13. PPSV23 blunts the immune response to PCV13 if PCV13 is given after PPSV23, although in children there is a smaller effect than in adults.
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This page was reviewed on July 29, 2014
Immunization Action Coalition  •  Saint Paul, MN
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This website is supported in part by a cooperative agreement from the National Center for Immunization and Respiratory Diseases (Grant No. 5U38IP000290) at the Centers for Disease Control and Prevention (CDC) in Atlanta, GA. The website content is the sole responsibility of IAC and does not necessarily represent the official views of CDC.