CDC currently has no plans to develop VISs for Pediarix, Twinrix, Kinrix, Quadracel, or Pentacel. When administering these combination vaccines, use the VISs for all component vaccines. For certain combination vaccines given to children, you can use the multi-vaccine VIS (which includes DTaP, Hib, HepB, polio, and PCV) and check the appropriate box(es), just as you would if you were administering the individual vaccines. If the multi-vaccine VIS is unavailable, you should use the individual vaccine VISs. A VIS was developed for MMRV (ProQuad, by Merck) because of its unique adverse reaction profile.