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  • Diphtheria
  • Contraindications & Precautions
  • Pertussis
  • Contraindications & Precautions
  • Tetanus
  • Contraindications & Precautions

What precautions should be observed when giving DTaP, DT, Tdap, or Td?

Precautions to these vaccines include:

  • A history of Guillain-Barré syndrome (GBS) within 6 weeks of receiving a tetanus toxoid-containing vaccine
  • A history of Arthus-type hypersensitivity reaction after receiving a previous tetanus or diphtheria toxoid-containing vaccine (defer vaccination until at least 10 years have elapsed since the last tetanus toxoid-containing vaccine)
  • A moderate or severe acute illness with or without fever
  • For pertussis-containing vaccines (DTaP and Tdap only): an additional precaution is a progressive or unstable neurologic disorder, including infantile spasms, uncontrolled seizures or progressive encephalopathy. DTaP and Tdap should be deferred until the neurologic status of the patient is clarified and stabilized.
Last reviewed: March 31, 2022

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