What is the schedule for MenB?

Both MenB vaccine products, Trumenba (MenB-Fhbp, Pfizer) and Bexsero (MenB-4C, GSK) are routinely given as a 2-dose series with doses administered at least 6 months apart. A 3-dose schedule is recommended for people who need rapid protection against MenB due to an increased risk of MenB disease. For the 3-dose schedule, dose 2 is given 1-2 months after dose 1 and dose 3 at least 6 months after dose 1.

Penbraya (MenABCWY, Pfizer) contains MenB-Fhbp (Trumenba) and is given as two doses, 6 months apart, when vaccination against all 5 serogroups is needed. For adolescents and adults not at increased risk (who need only one dose of MenACWY vaccine), if Penbraya is used, Trumenba should be administered to complete the 2-dose MenB series. For people age 10 years or older at increased risk of meningococcal disease, Penbraya may be used for additional MenACWY and MenB doses (including booster doses) when both vaccines would be given on the same clinic day and at least 6 months have elapsed since most recent Penbraya dose.

In August 2024, FDA revised the licensed schedule for Bexsero to be the same as the schedule and dosing intervals of the other MenB vaccine product, Trumenba. The change was made due to evidence of a small, but significant, improvement in the immune response to Bexsero when 2 doses were given 6 months apart, instead of 1 month apart, as previously licensed. As with Trumenba, a third dose of Bexsero is due, at least 4 months after the second dose and 6 months after the first, if dose 2 is given less than 6 months after dose 1. No additional doses are recommended for people who previously completed the 2-dose Bexsero series using a 1-month interval as licensed and recommended at the time.