We have a 19-year-old patient with a history of vasculitis, nephritis, and asthma. She is on azathioprine (Imuran) and is immunosuppressed. Her rheumatologist recommends she receive pneumococcal conjugate vaccine and meningococcal B vaccine. How often should these vaccines be given?

For people with immunosuppression, ACIP recommends 1 dose of PCV20 or one dose of PCV15 followed by a dose of PPSV23 one year later (can consider a minimum 8-week interval for immunocompromised adults). Meningococcal serogroup B vaccine (MenB) is not specifically recommended for immunosuppressed people. However, a patient who is age 16 through 23 years and immunosuppressed may receive routine MenB vaccination of either a 2-dose series of Bexsero (GSK) 4 weeks apart, or a 3-dose series of Trumenba (Pfizer) at 0, 1 month, and 6 months apart.