Ask the Experts: RSV (Respiratory Syncytial Virus): Contraindications & Precautions (Vaccines and Antibody)

Results (2)

Nirsevimab (Beyfortus, Sanofi) and clesrovimab (Enflonsia, Merck) are contraindicated in persons with a history of severe allergic reactions (e.g., anaphylaxis) after a previous dose of the same product or to a product component. As with any injection, when administering nirsevimab or clesrovimab to children with increased risk for bleeding, providers should follow ACIP’s general best practice guidelines for immunization of children with bleeding disorders: www.cdc.gov/vaccines/hcp/imz-best-practices/special-situations.html#cdc_report_pub_study_section_8-vaccinating-persons-with-increased-bleeding-risk.

Last reviewed: August 24, 2025

RSV vaccines are contraindicated for and should not be administered to persons with a history of severe allergic reaction, such as anaphylaxis, to any component of the vaccine. People experiencing moderate or severe acute illness with or without fever should delay RSV vaccination until they are improved, as a precaution.

Last reviewed: August 24, 2025

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