My patient, age 45, is immunocompromised and is recommended to receive a third dose of mRNA COVID-19 vaccine, but he has only ever received two monovalent mRNA doses more than 18 months ago. What do I do now?

The patient should receive a 2024–2025 COVID-19 mRNA dose now, if feasible, of the same brand as the initial two doses, in order to complete the 3-dose primary mRNA vaccine series recommended for people with moderate or severe immunocompromise. Advise the patient that he should receive an additional 2024–2025 Formula COVID-19 dose of any brand in 6 months (minimum interval 2 months), followed by additional doses (minimum interval 2 months apart) as needed, based on your clinical judgment, his preference, and his individual circumstances.