My 43-year-old patient who is about to undergo a splenectomy received PCV15 followed by PPSV23 eight weeks later in preparation for the procedure. When should she get her next dose of PPSV23?

ACIP and CDC do not recommend revaccination with a second dose of PPSV23 for adults 19 through 49 with asplenia who receive PCV15 (Vaxneuvance, Merck) followed by PPSV23.

If the adult patient with asplenia had received PCV13 (Prevnar 13, Pfizer) followed by PPSV23 (instead of Vaxneuvance), then CDC recommends administration of a dose of PCV20 or PCV21 at least 5 years after the dose of PPSV23.