Is it safe to give hepatitis B vaccine during pregnancy?

Many years of experience with Engerix-B and Recombivax HB vaccines and recent studies of Heplisav-B indicate no apparent risk for adverse events to a developing fetus. Current vaccines contain noninfectious HBsAg and pose no risk to the fetus. If the mother is being vaccinated because of a risk factor for HBV infection (for example, a healthcare worker, a person with a sexually transmitted disease, an injection drug user, a person with multiple sex partners), vaccination should be initiated as soon as the risk factor is identified during the pregnancy. HBV infection during pregnancy might result in severe disease for the mother and chronic infection for the newborn.

Any of the available HepB vaccines (Engerix-B, Heplisav-B, Recombivax HB) or the HepA-HepB combination vaccine, Twinrix, may be used during pregnancy.