I know the primary series of MenB vaccine should use the same brand for all doses. Does that also apply to booster doses?

Yes. MenB vaccines work differently and receiving mismatched MenB doses might result in inadequate protection. For this reason, documentation of the brand of vaccine is especially important. The two MenB products are MenB-4C (Bexsero, GSK) and MenB-FHbp (in Trumenba and the Penbraya brand of MenABCWY, both by Pfizer). If a patient at high risk requires a booster dose and the brand of the primary series doses cannot be determined or is unavailable, then CDC recommends restarting the primary series with the available brand.

The first MenB booster dose is recommended one year following completion of the primary series, with subsequent MenB booster doses every 2–3 years thereafter, as long as risk remains.

If a record shows that Penbraya (MenABCWY, Pfizer) was administered to a patient subsequent MenB doses should be Trumenba (or Penbraya, if MenABCWY is indicated).