How is recombinant zoster vaccine (RZV, Shingrix) administered?

Shingrix (GSK) is available in two presentations: a lyophilized powder that must be reconstituted using the accompanying adjuvant solution, or a manufacturer-filled syringe (MFS) that does not require reconstitution before administration.

If using the presentation that must be reconstituted, reconstitute Shingrix using only the adjuvant solution provided with the vaccine antigen. After reconstitution, administer Shingrix immediately by the intramuscular route or store the reconstituted vaccine refrigerated between 2° and 8°C (36° and 46°F) and use within 6 hours. Discard reconstituted vaccine if not used within 6 hours or if frozen. If Shingrix is reconstituted with other than the supplied adjuvant solution, it should be repeated. The dose can be repeated immediately. There is no interval that must be met between these doses.