Can all of the licensed Hib-containing vaccines be used interchangeably?

Yes, for the primary series. If either ActHIB (PRP-T), Hiberix (PRP-T), Vaxelis (DTaP-IPV-Hib-HepB), or Pentacel (DTaP-IPV/Hib) is used for a routine primary series dose, a complete routine primary series consists of three doses. PedvaxHIB (PRP-OMP) requires a 2-dose primary series, but if administering a mixed-product primary series including only one dose of PedvaxHIB, a total of 3 doses is needed to complete the primary series.

Vaxelis is not recommended for use as a Hib booster (4th) dose. A different Hib-containing vaccine licensed for the booster dose should be used. If Vaxelis is inadvertently given as the booster dose, the dose does not need to be repeated with another Hib-containing vaccine, if the proper spacing of prior doses is maintained.