Are the two MenB vaccines interchangeable?

No. The ACIP meningococcal serogroup B vaccine recommendations state that the same vaccine type (either MenB-4C, Bexsero [GSK] or MenB-FHbp, Trumenba [Pfizer]) must be used for all doses in the MenB series, including booster doses. If the brand of a previous dose is unavailable or cannot be determined, restart the primary series with the available brand. The pentavalent MenABCWY product Penbraya (Pfizer) contains MenB-FHbp (the same as Trumenba) as its MenB component; therefore, Penbraya should only be used in series with Trumenba.