Eligible healthcare professionals may administer Nuvaxovid (Sanofi-Novavax) COVID-19 vaccine to individuals 12 years of age and older, following clinical guidance from CDC (Interim Clinical Considerations for Use of COVID-19 Vaccines). A list of high-risk conditions supported by evidence is provided, along with a list of conditions that should trigger use of the dosing schedule for people with moderate or severe immunocompromise. CDC recommends COVID-19 vaccination of any person age 6 months or older following a shared clinical decision-making discussion. Links to current COVID-19 vaccine recommendations from AAP, AAFP, IDSA, and ACOG are also provided. These organizations recommend routine vaccination for designated people at increased risk of infection or severe disease and shared clinical decision-making for those at lower risk.