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Issue Number 610            July 17, 2006


  1. CDC releases revised interim Tdap VIS
  2. AHA and ACC recommend influenza vaccination for patients with cardiovascular disease
  3. CDC reports on 2004 varicella outbreak among vaccinated children in Nebraska
  4. NACCHO devotes journal issue to seasonal and pandemic influenza
  5. Clinical Vaccinology Course set for November 3–5 in Atlanta


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ABBREVIATIONS: AAFP, American Academy of Family Physicians; AAP, American Academy of Pediatrics; ACIP, Advisory Committee on Immunization Practices; CDC, Centers for Disease Control and Prevention; FDA, Food and Drug Administration; IAC, Immunization Action Coalition; MMWR, Morbidity and Mortality Weekly Report; NIP, National Immunization Program; VIS, Vaccine Information Statement; VPD, vaccine-preventable disease; WHO, World Health Organization.

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July 17, 2006

On July 12, 2006, CDC released a revised interim Vaccine Information Statement (VIS) for Tdap vaccine. It is identical to the previous interim version except for minor changes in Section 3 that reflect ACIP's evolving recommendations regarding use of Tdap during pregnancy.

It is not necessary to throw away copies of the previous version that have already been printed; however, pregnant women considering getting the vaccine should be made aware of the current recommendations.

A final Tdap VIS, an interim HPV VIS, an updated varicella VIS, and a zoster VIS are all in development.

To download the new interim VIS for Tdap, or any other VIS in English, go to CDC's VIS page at This page includes a link to VIS news about new and upcoming releases.

For VISs in more than 30 languages, go to:

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July 17, 2006

On May 16, 2006, the American Heart Association (AHA) and the American College of Cardiology (ACC) published guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease.

The paper states that a growing body of evidence supports the merits of aggressive risk-reduction therapies for patients with established coronary and other atherosclerotic vascular disease, including peripheral arterial disease, atherosclerotic aortic disease, and carotid artery disease.

One of the intervention recommendations is that patients with cardiovascular disease should receive influenza vaccination.

To read the complete article in the journal Circulation, go to:

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July 17, 2006

CDC published "Varicella Outbreak Among Vaccinated Children—Nebraska, 2004" in the July 14 issue of MMWR. A summary made available to the press is reprinted below.


Varicella vaccine was 81 percent effective in preventing varicella during an elementary school outbreak with significantly milder disease among vaccinated students compared to unvaccinated students and warrants improving varicella vaccination coverage. A varicella outbreak at an elementary school in Nebraska in November 2004 raised concerns about vaccine failure among vaccinated students. The public health investigation demonstrated that vaccine effectiveness was within the expected range (80–85 percent) and vaccinated cases had significantly milder disease. Since the licensure of varicella vaccine in the United States in 1995 and the subsequent nationwide implementation of a varicella vaccination program there has been a dramatic decline in cases, hospitalizations, and deaths related to varicella. However, varicella outbreaks continue to occur, involving both unvaccinated and vaccinated cases as was the case in this outbreak too. Implementation of broader school entry requirements (to include students from kindergarten to college) can increase vaccination coverage and reduce varicella morbidity. The Advisory Committee on Immunization Practices (ACIP) recently recommended a second dose of varicella vaccine for children 4–6 years old and a second dose catch-up vaccination for children, adolescents, and adults who previously had received one dose. The second dose is expected to provide protection to children. . . who do not adequately respond to the first dose and have an impact on school outbreaks.


To access a web-text (HTML) version of the complete article, go to:

To access a ready-to-print (PDF) version of this issue of MMWR, go to:

To receive a FREE electronic subscription to MMWR (which includes new ACIP statements), go to:

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July 17, 2006

The July–August 2006 issue of the Journal of Public Health Management and Practice is devoted to seasonal and pandemic influenza. The issue editors are Raymond A. Strikas, MD, and Nicole Smith, PhD, MPH, MPP. Both are with CDC. The journal is published by NACCHO (National Association of County and City Health Officials).

To access the article titles, go to:

To order the issue for $37.95, send an email message to

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July 17, 2006

The National Foundation for Infectious Diseases; the Emory Department of Medicine, Division of Infectious Diseases; and the Emory Vaccine Center are sponsoring a Clinical Vaccinology Course in Atlanta on November 3–5, 2006.

The course will provide the latest information on important developments in clinical vaccinology and the use of vaccines. The course is designed for physicians, nurses, physician assistants, pharmacists, vaccine program administrators, and other health professionals involved with the clinical use of vaccines. It will also present information of interest to public health officials involved in the prevention and control of infectious diseases.

For more information, including the agenda and list of course faculty, go to: Online registration is also available via this web page. Alternatively, you can call (301) 656-0003, extension 19, for more information.

About IZ Express

IZ Express is supported in part by Grant No. 1NH23IP922654 from CDC’s National Center for Immunization and Respiratory Diseases. Its contents are solely the responsibility of and do not necessarily represent the official views of CDC.

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Editorial Information

  • Editor-in-Chief
    Kelly L. Moore, MD, MPH
  • Managing Editor
    John D. Grabenstein, RPh, PhD
  • Associate Editor
    Sharon G. Humiston, MD, MPH
  • Writer/Publication Coordinator
    Taryn Chapman, MS
    Courtnay Londo, MA
  • Style and Copy Editor
    Marian Deegan, JD
  • Web Edition Managers
    Arkady Shakhnovich
    Jermaine Royes
  • Contributing Writer
    Laurel H. Wood, MPA
  • Technical Reviewer
    Kayla Ohlde

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