- "Vaccination Coverage by Age 24 Months Among Children Born in 2021 and 2022—National Immunization Survey-Child, United States, 2022–2024" published in MMWR
- American Academy of Family Physicians releases its 2026 recommended schedules for children and adolescents and for adults
- RSV activity continues in some parts of the United States; does your jurisdiction advise continuing RSV preventive antibody products for infants? See available information.
- National Public Health Week is April 6–12; honor the people who keep our communities healthy
- Measles 2026: 1,575 confirmed measles cases in 31 states; Michigan joins states with outbreak cases in 2026
- Vaccine-preventable respiratory virus update: influenza activity continuing to decline, RSV remains, and COVID-19 is low nationally
- “What Proof Do I Need Before Giving COVID-19 Vaccine to a Person Who Says He Is Immunocompromised?” See this 1-minute video, part of the Ask the Experts Video Series on YouTube.
- IZ Express is more important than ever to keep up to date on evidence-based vaccine information; be sure everyone in your organization who needs it subscribes
- Vaccines in the news
- CDC releases public health toolkit and infographic on sepsis prevention, highlighting benefits of vaccination
- New in Immunize.org shop! Laminated VIS QR code tables deliver CDC VISs directly to your patients’ smartphone (Spanish translation version also available).
- Updated 65+ Flu Defense website offers resources for healthcare professionals serving older adults
- Study finds no association between COVID-19 vaccination and sudden death in apparently healthy younger adults, published in PLOS Medicine
- “The Role and Safety of Aluminum Adjuvants in Childhood Vaccines” published in Pediatrics
- “Communicating About Vaccines in a Politically Contentious Climate” published in NEJM
- “COVID-19 mRNA Vaccination in Pregnancy and Risk of Infection in Early Childhood” published in Pediatrics
CDC published Vaccination Coverage by Age 24 Months Among Children Born in 2021 and 2022—National Immunization Survey-Child, United States, 2022–2024 on March 26 in MMWR. Key points from the abstract appear below.
- Declines in coverage of 1–2 percentage points were observed for childhood vaccination with Hib, the birth dose of HepB, ≥4 doses of pneumococcal conjugate vaccine, and rotavirus vaccine
- Coverage with at least two doses of influenza vaccine by age 24 months decreased substantially from 61.0% among children born during 2019–20 to 53.5% among those born during 2021–22, and varied widely by jurisdiction
- Coverage was substantially lower among VFC program–eligible children than among those who were not VFC-eligible and varied widely by jurisdiction
- Compared with non-Hispanic White children, coverage with many vaccines was lower among non-Hispanic Black or African American and Hispanic or Latino children; coverage was highest among non-Hispanic Asian children
- Coverage was lower among children living in poverty and those living in more rural areas
Work is needed to improve coverage to address these declines and disparities in early childhood vaccination. Improving coverage among groups and in areas in which rates declined will more effectively protect children from vaccine-preventable morbidity and mortality.
Access the MMWR article in HTML or PDF.
Related Link
- CDC: MMWR main page providing access to the MMWR family of publications
American Academy of Family Physicians releases its 2026 recommended schedules for children and adolescents and for adults
On March 24, American Academy of Family Physicians (AAFP) released its 2026 immunization schedules. The AAFP's guidance aligns with the AAP's 2026 childhood schedule and carries forward the 2025 adult schedule with targeted updates. Both schedules provide clear, practical, evidence-based recommendations. Immunize.org added the schedules to the Healthcare Professionals Organization Schedules main page for easy access.
The recommendations covered by the Birth Through Age 18 Immunization Schedule do not differ from the AAP childhood schedule.
Key updates to the Adults 19 and Older Immunization Schedule include:
- Revised product listings, removing PreHevbrio (no longer available) and adding pentavalent Penmenvy (GSK) to trade-name listings and notes, with approved-use guidance
- Revised RSV-related notes and tables supporting strong recommendations and confident physician-patient conversations
AAFP Chief Medical Officer Margot Savoy, MD, MPH, published a blog outlining the 2026 updates in detail. AAFP’s patient-facing website, familydoctor.org, includes vaccine facts, information by age group, advice for protection from respiratory illnesses, and “what your doctors say about vaccines.”
Related Links- AAFP: Immunizations and Vaccines main page
- AAFP: AAFP Voices blog
- AAP's website, familydoctor.org: Vaccines: Myth Versus Fact web page
- Immunize.org: Healthcare Professional Organization Schedules main page
RSV activity continues in some parts of the United States; does your jurisdiction advise continuing RSV preventive antibody products for infants? See available information.
RSV preventive antibody products, nirsevimab (Beyfortus, Sanofi) and clesrovimab (Enflonsia, Merck), are typically recommended from October through March in most of the contiguous United States, but according to data from the National Respiratory and Enteric Viruses Surveillance System, elevated RSV activity is persisting into April in some regions this season. CDC encourages jurisdictions to review local data and consider extending administration beyond March, particularly for newborns.
The Association of Immunization Managers (AIM) collected current RSV preventive antibody guidance from jurisdictions. As of March 27, most jurisdictions are extending recommended preventive antibody use to April 30. If you don't see your jurisdiction listed, contact your immunization program directly. IZ Express will continue to update this information as it becomes available.


Related Links
- AAP: RSV Immunization Administration Frequently Asked Questions web page
- Immunize.org: Standing Orders for Administering Nirsevimab RSV Preventive Antibody (Beyfortus, by Sanofi) to Infants and High-Risk Young Children (PDF)
- Immunize.org: Standing Orders for Administering Clesrovimab RSV Preventive Antibody (Enflonsia, by Merck) to Infants (PDF)
- Immunize.org: Vaccines A–Z: RSV (Respiratory Syncytial Virus) main page
- Association of Immunization Managers: Immunization Program Directory web page
National Public Health Week (NPHW), observed April 6–12, is a time to recognize the community health workers, medical professionals, scientists, and advocates whose work protects our health, including the immunization providers who keep vaccine-preventable diseases at bay.
This year's theme, "Ready. Set. Action!" is a call to reflect on public health's remarkable track record and recommit to the work ahead. For more than 150 years, public health efforts dramatically extended life expectancy and improved the quality of life. Vaccination programs are central to the progress of public health.
Visit nphw.org to find events, tools, and resources for National Public Health Week.

Looking for a meaningful way to honor an immunization provider? Immunize.org's Vaccination Saves Lives lapel pins make elegant gifts or workplace recognitions, and are a great way to show commitment to vaccines year-round. The refined blue enamel and gold pin is available with either a traditional double stick-through post or new magnetic clasp backing.

Click here for Vaccination Saves Lives pin pricing and ordering information.
Measles 2026: 1,575 confirmed measles cases in 31 states; Michigan joins states with outbreak cases in 2026
As of March 26, CDC reports 1,575 confirmed measles cases in 2026. In comparison, throughout 2025, 2,285 measles cases were reported in the United States. So far, 31 states reported measles cases in 2026.
- The Michigan Department of Health and Human Services and Washtenaw County Health Department confirmed a measles outbreak with three linked cases reported since March 12
- South Carolina confirmed 997 measles cases since its outbreak began in October 2025
- The Florida Department of Health confirmed 123 cases
A chart of cumulative measles cases reported in the United States since 2018, as of March 14, from the Johns Hopkins International Vaccine Access Center, appears below. The chart underscores the rapid pace of the spread of measles this year.

Immunize.org offers measles-related resources for the public on several of our affiliated websites:
- VaccineInformation.org: Measles web page
- LetsGetRealAboutVaccines.org: Measles web page
- Immunize.org: Vaccines A–Z: Measles main page
- AAP: Fact Checked: The MMR (Measles, Mumps and Rubella) Vaccine Is Safe and Effective web page
- CDC: Measles Cases and Outbreaks main page
- Common Health Coalition: More Illness, Greater Cost: Spotlight Brief; Childhood Immunizations (PDF)
- Pophive (Yale School of Public Health): Infectious Diseases Dashboard: Measles web page
- Health Canada: Measles and Rubella Weekly Monitoring Report
- Immunize.org: Vaccines A–Z: Measles main page
Vaccine-preventable respiratory virus update: influenza activity continuing to decline, RSV remains, and COVID-19 is low nationally
Nationwide respiratory virus activity reported by CDC is highlighted below.
- Influenza (data through March 21):
- Seasonal influenza activity trending downward across the country, with high or very high levels of influenza-like illness (ILI) reported in 4 jurisdictions
- There have been at least 29 million illnesses, 360,000 hospitalizations, and 23,000 deaths from flu so far this season according to CDC estimates
- Deaths of 8 more children were reported during week 11, for a total of 123 child deaths with influenza reported so far this season
- RSV:
- The Epidemic Trends map shows that RSV activity is increasing or unchanged in parts of the northern United States
- Respiratory Illnesses Data Channel states that RSV activity started later than expected in most regions, and higher levels of RSV activity may continue into April
- Consult state public health authorities for guidance on how long to continue administering RSV preventive antibody products to infants as the RSV season persists
- COVID-19: Activity is decreasing nationally
Level of Respiratory Illness Activity
The ILI map is shown below.

RSV epidemic trends are shown below:

Vaccination against COVID-19, influenza, and RSV reduces the risk of severe illness and should continue as long as disease is circulating locally. Immunization of eligible infants against RSV is crucial while RSV is circulating. Follow guidance of public health officials for RSV immunization recommendations beyond March.
“What Proof Do I Need Before Giving COVID-19 Vaccine to a Person Who Says He Is Immunocompromised?” See this 1-minute video, part of the Ask the Experts Video Series on YouTube.
This week, our featured episode from the Ask the Experts Video Series is titled What Proof Do I Need Before Giving COVID-19 Vaccine to a Person Who Says He Is Immunocompromised? The video explains that a patient's self-reported risk for severe COVID-19, including immunocompromise, is sufficient; vaccinators should not deny vaccination due to a lack of documentation.
The 1-minute video is available on our YouTube channel, along with our full collection of quick video answers to popular Ask the Experts questions.

Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.
- Facebook at ImmunizeOrg
- Instagram at ImmunizeOrg
- LinkedIn at ImmunizeOrg
- YouTube at ImmunizeOrg
IZ Express is more important than ever to keep up to date on evidence-based vaccine information; be sure everyone in your organization who needs it subscribes
Now more than ever, vaccinators need accurate, up-to-date immunization news at their fingertips. Encourage your coworkers to subscribe to IZ Express so they get all the news that matters to vaccinators in their own inbox each Wednesday. It’s free!
IZ Express also features:
- Educational materials from Immunize.org and other trustworthy organizations
- Newly posted VISs and their translations
- Notices about educational opportunities, many offering free continuing education credit
Thank you for helping us get the latest vaccine news to every clinical and public health professional who needs to know.
These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
- Guardian: US Left Without Functioning Vaccine Panel as Adviser Says ‘Drama Distracts’ (3/25/26)
- Scientific American: U.K.’s Deadly Meningitis Outbreak Shows Importance of Vaccination (3/21/26)
- National Catholic Reporter: Amid Measles Uptick, Infectious Diseases Specialist Says Church Recommends Vaccination (3/13/26)
Immunize.org updated its Strategies to Improve Adult Vaccination Coverage document for healthcare providers. Edits update references and links to external resources.
Immunize.org updated its Skills Checklist for Vaccine Administration document for healthcare staff who administer immunizations. Edits update the links to external resources.
IZ Express regularly provides readers with information about Immunize.org’s new and updated educational materials for healthcare professionals and patient handouts. All Immunize.org materials are free to distribute.
In case you missed them during recent weeks, the following updated materials were posted for clinicians:
- Adult Immunization: Importance of Staying Up to Date with Vaccines
- Vaccine Storage Emergency Response Worksheet
- Leading Medical Organizations Endorse Strong School and Childcare Vaccination Requirements and Elimination of Non-Medical Exemptions
- Standing Orders for Administering:
- Clesrovimab RSV Preventive Antibody (Enflonsia, by Merck) to Infants
- Diphtheria, Tetanus, and Acellular Pertussis (DTaP) Vaccine to Children Younger Than Age 7 Years
- Haemophilus influenzae Type B to Children & Teens
- Hepatitis A Vaccine to Children and Teens
- Hepatitis B Vaccine to Children and Teens
- Human Papillomavirus Vaccine to Children and Teens
- Inactivated Poliovirus Vaccine to Infants and Children
- Measles, Mumps, and Rubella Vaccine to Children and Teens
- Meningococcal ACWY Vaccine to Children and Teens
- Meningococcal B (MenB) Vaccine to Adolescents and Adults
- Nirsevimab RSV Preventive Antibody (Beyfortus, by Sanofi) to Infants and High-Risk Young Children
- Pfizer Respiratory Syncytial Virus (RSV) Vaccine (Abrysvo) During Pregnancy
- Pneumococcal Vaccines to Children and Teens
- Rotavirus Vaccine to Infants
- Tdap/Td Vaccine to Children and Teens Age 7 Years and Older
- Varicella Vaccine to Children and Teens
- Website section:
- Website Office Hours webinars and training videos:
Featured Resources
CDC released its Get Ahead of Sepsis toolkit, with practical tools to educate people about preventing infections, recognizing sepsis early, and acting fast. Sepsis is the body's extreme response to an infection, a life-threatening medical emergency. Among adults each year in the United States, sepsis leads to 1.7 million hospitalizations and at least 350,000 deaths. One in three people who die in a hospital had sepsis during their hospitalization.
Vaccination can significantly reduce sepsis risk by preventing primary infections with pneumococcus, Haemophilus influenzae, and meningococcus. While not all sepsis is preventable, many cases and deaths are avoided annually by vaccination, particularly by preventing infections that cause sepsis in children and the elderly.
CDC's toolkit highlights staying up to date on recommended vaccines as a key prevention step, along with good hand hygiene and proper wound care. The toolkit includes educational materials, social media graphics and messages, and customizable drop-in articles for newsletters and publications. Resources are available for multiple audiences, including parents, youth organizations, and public health partners.

View the toolkit.
New in Immunize.org shop! Laminated VIS QR code tables deliver CDC VISs directly to your patients’ smartphone (Spanish translation version also available).
The Immunize.org team is pleased to introduce durable, laminated tables of QR codes linking to VISs for vaccines given to children and adults. VISs explain both risks and benefits of vaccination. Federal law requires you to document provision of CDC’s current VIS before administering any vaccine covered by the Vaccine Injury Compensation Program. CDC recommends VISs accompany other vaccines, too. An easy, paperless way to comply with the law is for patients to scan a QR code and access the VIS from a smartphone or tablet.
CDC produces official VISs only in English. CDC does not produce or certify available translations, so the official CDC VIS should accompany any translation.
These new tables belong in any room where vaccinations are given. Key features include:
- Durable quality: The tough laminate coating can be wiped down.
- Never out-of-date: Any time a VIS or translation is updated, the QR code will direct to the new VIS.
- Use as a booklet or poster: The laminated table arrives folded like a newspaper. It is suitable for desk use as an 8.5" x 11" booklet or wall mounted as an 11" x 17" poster.
- One version for official CDC VISs and one for Spanish translations: The table of official CDC VISs in English is sold individually. The table of Spanish translations is sold as a bundle with the table of official VISs so it is easy to make both available.
- Spanish version usable by non-Spanish speakers: The Spanish QR code table has side-by-side text in English to support its use by non-Spanish speakers.
- Easy access to all available translations: Both versions include a QR code link to the Immunize.org index of all VIS translations available in dozens of languages.
- Bonus content: The reverse side of the QR code poster includes links to Immunize.org's “Addressing Vaccination Anxiety” resources and additional VIS content.
Pricing (includes all shipping and handling costs)
Laminated CDC VIS QR Code Table (English)
1 copy: $14.00
2 copies: $9.00 each
3–4 copies: $6.50 each
5–9 copies: $5.00 each
10–19 copies: $4.00 each
20–59 copies: $3.00 each
60+ copies: $2.50 each
Bundle: Laminated CDC (English) + Spanish Translation VIS QR Code Tables
(each bundle includes 1 CDC VIS table and 1 table of Spanish translations)
1 bundle: $20.00
2 bundles: $16.00 each
3–4 bundles: $12.00 each
5–9 bundles: $8.50 each
10–19 bundles: $7.00 each
20–59 bundles: $6.00 each
60+ bundles: $5.00 each

Visit the Shop Immunize.org: Laminated VIS QR Code Tables web page to view images and order today! For additional information, call 651-647-9009 or email admininfo@immunize.org.
Confident healthcare provider recommendations for influenza vaccine are powerfully persuasive. As the nation faces a challenging influenza season, Immunize.org, in collaboration with CSL Seqirus, updated the 65+ Flu Defense website to help you maximize patient protection.

This helpful site includes information, tools, and tips for communicating with adults age 65 and older about the burden and severity of influenza. Resources include:
- Influenza in Adults 65+: The Facts
- Influenza Vaccination: Questions Patients Aged 65 and Older Frequently Ask Their HCP
- The Importance of Preventing Influenza and COVID-19
A clinician recommendation is the most important reason why a person will get vaccinated. Check out the updated 65+ Flu Defense website to assist your ongoing efforts in protecting this vulnerable population.
In its March 19 issue, PLOS Medicine published Association Between COVID-19 Vaccination and Sudden Death in Apparently Healthy Younger Individuals: A Population-Based Case-Control Study. No association was found. A portion of the author summary appears below.
- A case-control study was conducted involving Ontario residents aged 12–50 years without documented comorbidities predisposing to premature death between April 1, 2021 and June 30, 2023 to examine the association between COVID-19 vaccination and sudden death
- The primary outcome was sudden death; the exposure of interest was any COVID-19 vaccination
- Among 6,365,451 eligible individuals, 4,806 cases who experienced sudden death were matched to 24,030 controls who were alive on the date of sudden death for each corresponding case
- Receipt of COVID-19 vaccination was not associated with increased odds of sudden death . . .
- These findings do not support the hypothesis that COVID-19 vaccines increase the risk of sudden cardiac death in younger healthy adults
On February 25, Pediatrics published The Role and Safety of Aluminum Adjuvants in Childhood Vaccines. Studies show that aluminum released from intramuscular vaccines is slowly absorbed and efficiently cleared by the kidneys, contributing minimally to systemic levels. Large-scale studies consistently demonstrate no association between aluminum-adjuvanted vaccines and autism spectrum disorder, neurotoxicity, allergic disease, or autoimmune disease. A portion of the abstract appears below.
Aluminum salts have been used as adjuvants in vaccines for nearly a century, enhancing the immune response to purified antigens and ensuring durable protection against serious infectious diseases. Despite their longstanding record of safety and effectiveness, aluminum adjuvants have become a focus of public concern, with claims linking them to developmental, neurologic, allergic, and autoimmune diseases. This review summarizes the immunologic rationale for aluminum adjuvants and evaluates the evidence for proposed safety risks. . . . Collectively, the evidence strongly supports the safety of aluminum adjuvants and their necessity in certain vaccines. Clinicians can reassure caregivers that aluminum-containing vaccines provide clear benefits, with risks largely limited to transient local reactions and no systemic toxicity signal in large clinical and epidemiologic studies.
View the video.

Related Link
- Immunize.org: Adjuvants: Resources and Information main page
In its March 21 issue, NEJM published Communicating About Vaccines in a Politically Contentious Climate. A portion of the article appears below.
Given the multitude of federal vaccine policy changes and the historical and anticipated struggles in communicating with parents about vaccines with an SDM [shared decision-making] recommendation, clinicians may find these conversations increasingly difficult. In this context, it may be helpful to remember what has remained constant: pediatric clinicians have been and continue to be parents’ most trusted source of reliable information about vaccines. It is important that clinicians both draw on this trust and nurture it.
To do so, pediatric clinicians should be careful about expressing a political stance or making overt political references in their vaccine discussions with parents. As decisions about whether to vaccinate become increasingly associated with political ideology, politics may more frequently enter these discussions. To avoid alienating parents and eroding trust, pediatric clinicians should engage about politics only when parents voice their own political views and should do so only to learn more about how those views are influencing their vaccine decision making.
An audio interview accompanies this article.

In its March 20 issue, Pediatrics published COVID-19 mRNA Vaccination in Pregnancy and Risk of Infection in Early Childhood. COVID-19 vaccination during pregnancy protects the offspring against hospital contact for COVID-19 during the first 6 months of life. A portion of the video abstract appears below.
Among 146,031 infants born in Norway in the study period, 37,013 (25%) were exposed to COVID-19 vaccination in pregnancy. There was no difference in the overall risk of any infection registered in specialist care among offspring exposed to maternal vaccination . . . The offspring’s protection against COVID-19 decreased over time . . . No notable difference in the risk of hospital contacts for infections other than COVID-19 was observed.
A video abstract accompanies this article.

Health authorities are responding to a large outbreak of meningococcal B meningitis reported in Kent, England. The response includes targeted antibiotic treatment and MenB vaccination.
The UK Health Security Agency (UKHSA) is reminding teenagers and adults that two doses of MenB vaccine are needed for protection.
In the United States, CDC, the American Academy of Pediatrics, and the American Academy of Family Physicians recommend MenB for people age 10 and older who are at increased risk for meningococcal type B disease, including those with certain immune conditions (e.g., asplenia) and those at risk during outbreaks. For healthy people age 16 through 23 years who are not exposed to an outbreak, MenB vaccination is recommended based on shared clinical decision-making.
Because this is an active and evolving situation, UKHSA updates its Meningitis Outbreak: What You Need to Know blog page regularly.
Related Links
- UKHSA: Meningitis Outbreak: What You Need to Know blog
- WHO: Meningitis B Outbreak in the United Kingdom web page
- Immunize.org: Vaccines A–Z: Meningococcal B main page
To learn simple tips and tricks for using our websites efficiently, please register for our next set of Website Office Hours on Wednesday, April 8, at 4:00 p.m. (ET) or Thursday, April 9, at 12:00 p.m. (ET). The same content will be covered in both sessions.
We will open each 30-minute session with a short, live demonstration on navigating our About Us, Publication Archives, and Vaccine Timeline website sections. You can submit questions when you register or live on Zoom during the session.

Register today for Immunize.org Website Office Hours (content is the same for both):
The archive of previous Website Office Hours content is posted at Immunize.org’s "Webinars & Videos" page.
Mark your calendar for future Immunize.org Website Office Hours.
For more upcoming events, visit our Calendar of Events.
About IZ Express
IZ Express is supported in part by Grant No. NH23IP922654 from CDC’s National Center for Immunization and Respiratory Diseases. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.
IZ Express Disclaimer
ISSN 2771-8085
Editorial Information
-
Editor-in-ChiefKelly L. Moore, MD, MPH
-
Managing EditorJohn D. Grabenstein, RPh, PhD
-
Associate EditorSharon G. Humiston, MD, MPH
-
Writer/Publication CoordinatorTaryn Chapman, MS
Courtnay Londo, MA -
Style and Copy EditorMarian Deegan, JD
-
Web Edition ManagersArkady Shakhnovich
Jermaine Royes -
Technical ReviewerKayla Ohlde

