IZ Express

Issue 1824: July 23, 2025

Top Stories
 
Immunize.org Website and Clinical Resources 
 
Featured Resources

Notable Publications
 
Global News
 
Upcoming Events

Top Stories

Study finds no relationship between aluminum in vaccines and a wide variety of chronic childhood health problems

In its July 15 issue, Annals of Internal Medicine published Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood. This large study in Denmark found no evidence of a relationship between the use of aluminum-containing vaccines and 50 different disorders affecting children. The results of this study are timely and reassuring, given renewed media attention and questions raised about the safety of aluminum in vaccines. A portion of the results section appears below. 

Cumulative aluminum exposure from vaccination during the first 2 years of life was not associated with increased rates of any of the 50 disorders assessed. For groups of combined outcomes, adjusted hazard ratios per 1-mg increase in aluminum exposure were [unchanged] . . . for any autoimmune disorder, . . . any atopic or allergic disorder, and . . . any neurodevelopmental disorder. For most individually analyzed outcomes, the upper bounds of the 95% CIs were incompatible with relative increases greater than 10% or 30%. 



Related Link


Vaccinate Your Family launches back-to-school vaccination awareness campaign; spread the word using its FirstDayVax toolkit in English and Spanish 

Vaccinate Your Family (VYF) launched its #FirstDayVax campaign to remind families that vaccines should be part of every back-to-school checklist. This campaign celebrates the protection vaccines provide and empowers parents with information to make timely, informed choices. Find the shareable assets in the #FirstDayVax toolkit, also available in Spanish.



To extend the campaign's reach, use the #FirstDayVax hashtag on social media and tag @vaccinateyourfamily (@vaxyourfam on X).


FDA licenses prefilled syringe option for Shingrix (GSK) to prevent shingles

On July 17, FDA licensed the prefilled syringe option for Shingrix (GSK) for the prevention of shingles. Prefilled syringes are simpler to use than the 2-vial Shingrix package that requires a reconstitution step.

ACIP and CDC recommend vaccination of the following people to prevent shingles and post-herpetic neuralgia, the chronic pain that may linger long after the acute shingles rash resolves:

  • All adults age 50 years and older who have not received Shingrix
  • Adults age 19 years and older with a weakened immune system because of disease or treatments

Related Links


Measles spreads further, with 1,309 cases across 39 states

As of July 16, CDC reported 1,309 confirmed measles cases in 2025 in 39 states, including the first cases reported this year in South Carolina. Among confirmed cases of all ages, 13% were hospitalized. Among those younger than age 5 years, 21% were hospitalized.

CDC only requires reporting of laboratory-confirmed measles cases. Cases without laboratory testing for confirmation are not included in these numbers. Actual numbers of cases are, therefore, higher than confirmed case counts.

A map of 2025 measles cases in the contiguous United States, as of July 17, from the Johns Hopkins International Vaccine Access Center, appears below. The U.S. Measles Tracker website includes state and county-level data.

Immunize.org offers measles-related resources for the public on several of our affiliated websites:



Other credible sources include:

Related Links

Alternative vaccination schedules: watch the 2-minute explanation, part of the Ask the Experts Video Series on YouTube 

This week, our featured episode from the Ask the Experts Video Series is titled Alternative Schedules. The video describes how there is no scientific evidence of any benefit to delaying or separating vaccinations beyond the published recommended schedule of childhood vaccinations. In fact, delaying vaccination unnecessarily prolongs a child’s risk of infection. 

The 2-minute video is available on our YouTube channel, along with our full collection of quick video answers to popular Ask the Experts questions.

Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.


Vaccines in the news

These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.


Immunize.org Website and Clinical Resources

Spotlight on the website: Web page footer links lead to Immunize.org information  



This week’s Spotlight focuses on the content found at the bottom of each web page of Immunize.org.

“Our Affiliated Sites” section provides links to six websites that are part of and maintained by our 501(c)3 nonprofit organization. Each reflects various aspects of our mission. 

  • VaccineInformation​.org: providing resources to the public about vaccines and vaccine-preventable diseases 
  • ImmunizationCoalitions​.org: providing information to coalitions about and for the National Network of Immunization Coalitions 
  • LetsGetRealAboutVaccines​.org: answering parents’ and providers’ questions about pediatric vaccines and diseases 
  • Influenza-defense​.org: the 65+FluDefense site sharing the essentials of protecting older adults from seasonal influenza
  • Give2MenAcwy​.org: sharing resources to support vaccination with two doses of MenACWY vaccine to fully protect adolescent patients 
  • Izsummitpartners​.org: the National Adult and Influenza Immunization Summit (NAIIS) site provides information and resources for the many partner organizations that address influenza and adult vaccination issues  

The dark-blue box below the affiliated sites links to: 

  • Our social media pages
    • Facebook 
    • Instagram 
    • LinkedIn 
    • YouTube 
  • Information about Immunize.org, including "Our Mission" and "Our People" 
  • Ways to support our work: “Shop” and “Donate”
  • How to contact us, including an online form and telephone
  • Subscription information for IZ Express 

To learn more, watch these related videos:  


Featured Resources

ACOG shares new Maternal Immunization Social Media Toolkit with messaging and training for patients and clinicians  

The American College of Obstetricians and Gynecologists (ACOG) released its Maternal Immunization Social Media Toolkitdesigned to provide healthcare professionals with ready-to-use social media messaging to promote the COVID-19, influenza, RSV, and Tdap vaccines during pregnancy. Messages available are specific for either patient or clinician audiences.

The toolkit features sample posts, resources, and graphics to keep patients informed and to encourage your networks to promote maternal immunization. While the messages, resources, and graphics are endorsed by ACOG, language can be adapted to suit your own voice. 



Please share the Maternal Immunization Social Media Toolkit with partners who can spread these messages further.


Use Immunize.org's "Key Vaccination Resources for Healthcare Professionals" to train new and seasoned staff

Immunize.org offers an annotated list of key training, education, and reference materials for people who vaccinate or oversee vaccination clinics. Key Vaccination Resources for Healthcare Professionals provides vaccinators with a strong foundation for building and sustaining vaccination skills.

Related Links


Teaching children and teens about vaccination: reliable resources on how vaccines work

Planning for the upcoming school year or looking for science projects? The resources below can help children and adolescents explore vaccines and the immune system.

For elementary school children

For middle school children For high school students
 

Immunize.org's elegantly designed "Vaccines Save Lives" black enamel pins remind patients and families why we work so hard to prevent disease 

Immunize.org’s elegantly designed “Vaccines Save Lives” pins are meaningful gifts for people who care about vaccination. The pin makes a refined statement in hard black enamel with gold lettering and edges, measuring 1.125" x 0.75". The pin features a stick-through-post with the back covered by a round rubber cap that holds the pin securely. A gold metal spring-lock clasp is also provided.


Wear these pins on clothing, uniforms, and white coats to show that you value vaccines.

  

Click here for "Vaccines Save Lives" pin pricing and ordering information.


Notable Publications

“Vaccination as a New Form of Cardiovascular Prevention: a European Society of Cardiology Clinical Consensus Statement . . .” published in European Heart Journal 

In its June 30 issue, European Heart Journal published Vaccination as a New Form of Cardiovascular Prevention: a European Society of Cardiology [ESC] Clinical Consensus Statement: With the contribution of the European Association of Preventive Cardiology (EAPC), the Association for Acute CardioVascular Care (ACVC), and the Heart Failure Association (HFA) of the ESC. Although issued by European cardiology societies, the evidence and cardiac benefits described are relevant to the American population. Heart disease is the leading cause of death in the United States. The importance of vaccination to cardiovascular health is underappreciated by healthcare professionals and the public. The abstract is printed below. 

Vaccination is increasingly acknowledged as an effective preventive measure not only against specific infections, but also for the prevention of cardiovascular disease in high-risk patients. Specifically, a growing body of evidence suggests that vaccines against influenza, SARS-CoV-2, respiratory syncytial virus, herpes zoster, and other viruses significantly reduce infection and for influenza the incidence of major adverse cardiovascular events in vaccinated individuals.

This clinical consensus statement examines the existing literature and accumulated evidence and offers practical clinical advice on vaccination timing and target demographics, specifically addressing complex clinical scenarios with a focus on cardiovascular conditions. It includes guidelines for vaccinating vulnerable populations such as immunosuppressed individuals, patients with congenital heart disease, and pregnant women as well as safety and potential complications of the procedure.



Geographical Abstract Pathogens with increased cardiovascular (CV) risk: vaccine prevention against pathogens such as influenza and pneumococcus can reduce the risk for major adverse cardiovascular events (MACE). The benefit is particularly strong in susceptible risk groups such as older individuals, patients with congenital heart disease, heart transplant or coronary artery disease, as well as in pregnant women. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, RSV, respiratory syncytial virus.


“Disparities in Rural and Urban Outcomes in Populations with Human Papillomavirus–Associated Oropharyngeal Cancers” published in Journal of Rural Health 

In its July 10 issue, Journal of Rural Health published Disparities in Rural and Urban Outcomes in Populations with Human Papillomavirus–Associated Oropharyngeal Cancers. This retrospective study used the Surveillance, Epidemiology, and End Results (SEER) Pharyngeal Cancer with HPV Status Database from 2006 to 2018. Among people diagnosed with HPV-associated oropharyngeal cancer, the study assessed the difference in overall survival and cause-specific mortality between rural and urban populations.

An excerpt from the abstract appears below.

Results: A total of 13,294 patients were included in our study, most of whom lived in urban counties (88.5%, n = 11,766), had a mean age of 60.6 years . . . and had a primary tumor site located in the tonsil (47.6%, n = 6328). Rural communities had a higher likelihood of all-cause mortality . . . compared to their urban counterparts. Additionally, rural residents had a higher probability of cause-specific mortality . . . compared to their urban counterparts.

Conclusions: Patients with HPV-associated oropharyngeal cancer who reside in rural areas were more likely to die when compared to their urban counterparts. More research is needed to determine the best way to mitigate this disparity.

HPV vaccination is crucial to preventing HPV-associated cancers, but HPV vaccination rates are lower among rural teens than teens in urban areas. One way these disparities in disease outcomes can be addressed over time is by reducing disparities in rural and urban HPV vaccination rates and increasing HPV vaccination overall.


Global News

WHO and UNICEF issue joint press release on global immunization coverage for 2024, highlighting troubling trajectory in progress toward global immunization target for 2030 

On July 15, WHO and UNICEF issued a joint press release titled Global Childhood Vaccination Coverage Holds Steady, Yet over 14 Million Infants Remain Unvaccinated – WHO, UNICEF. At the same time, WHO released its summary of immunization coverage. A portion of the summary appears below. 

While immunization is one of the most successful public health interventions, coverage has held steady since 2023, but data highlight a troubling trajectory in progress toward key targets of the global Immunization Agenda 2030 (IA2030).  

During 2024, about 85% of infants worldwide (109 million) received 3 doses of diphtheria-tetanus-pertussis (DTP3) vaccine, protecting them against infectious diseases that can cause serious illness and disability or be fatal. However, these global figures hide significant disparity among countries of different income strata, with low-income countries lagging behind.

Measles, because of its high transmissibility, acts as an early warning system, quickly exposing immunity gaps in the population. Still, 20.6 million children missed their routine first dose of measles, far from the 2019 level of 19.3 million.



Related Links


Upcoming Events

Virtual: Register for Immunize.org Website Office Hours. Ask questions and learn about the “Official Guidance” (state resources) web section on Immunize.org on August 6 at 4:00 p.m. (ET) or August 7 at 12:00 p.m. (ET). Recorded sessions archived.

To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, August 6 at 4:00 p.m. (ET) or Thursday, August 7 at 12:00 p.m. (ET). The same content will be covered in both sessions.

We will open each 45-minute session with a short, live demonstration on navigating the Official Guidance (state resources) website section on Immunize.org. This section is useful for those who want to know about state immunization requirements for school and childcare. You can submit questions when you register or live on Zoom during the session.

Register today for Immunize.org Website Office Hours (content is the same for both):

The archive of previous Website Office Hours content is posted at Immunize.org’s "Webinars & Videos" page. These archived programs include Ask the Experts; Clinical Resources; Vaccine Information Statements (VISs); Affiliated Websites; Images, Webinars, Videos, & Social Media; Let's Get Real About Vaccines Website; News & Updates; Official Guidance Part 1 & 2; Publication Archives, Vaccine Timeline, & About Us; Travel Vaccines, Vaccine Confidence, & Addressing Concerns; and Vaccines A–Z.

Mark your calendar for future Immunize.org Website Office Hours.


For more upcoming events, visit our Calendar of Events.

About IZ Express

IZ Express is supported in part by Grant No. NH23IP922654 from CDC’s National Center for Immunization and Respiratory Diseases. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.

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Editorial Information

  • Editor-in-Chief
    Kelly L. Moore, MD, MPH
  • Managing Editor
    John D. Grabenstein, RPh, PhD
  • Associate Editor
    Sharon G. Humiston, MD, MPH
  • Writer/Publication Coordinator
    Taryn Chapman, MS
    Courtnay Londo, MA
  • Style and Copy Editor
    Marian Deegan, JD
  • Web Edition Managers
    Arkady Shakhnovich
    Jermaine Royes
  • Contributing Writer
    Laurel H. Wood, MPA
  • Technical Reviewer
    Kayla Ohlde

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