Home / Ask The Experts / When reconstituted, the volume of Shingrix is more than 0.5 mL. Should the entire volume of reconstituted vaccine be administered or just 0.5 mL as indicated in the package insert?

Zoster (Shingles)
Administering Vaccines

When reconstituted, the volume of Shingrix is more than 0.5 mL. Should the entire volume of reconstituted vaccine be administered or just 0.5 mL as indicated in the package insert?

The Shingrix adjuvant solution may contain up to 0.75 mL of liquid. The entire volume of the adjuvant solution should be withdrawn and used to reconstitute the lyophilized vaccine. After mixing, withdraw the recommended dose of 0.5 mL. Discard any reconstituted vaccine left in the vial.

Last reviewed: March 9, 2022

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This page was updated on March 9, 2022.