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  • HPV (Human Papillomavirus)
  • Contraindications & Precautions

What are the contraindications and precautions to HPV vaccine?

Contraindications are the following:

  • HPV vaccine is contraindicated for persons with a history of immediate hypersensitivity to any vaccine component, including yeast.
  • The precaution to HPV vaccine is a moderate or severe acute illness with or without fever. Vaccination should be deferred until the condition improves.

HPV vaccines are not recommended for use during pregnancy. If a person is found to be pregnant after starting the vaccination series, the remainder of the 2 or 3-dose series (depending on the age of first HPV vaccination) should be delayed until completion of pregnancy. Pregnancy testing is not needed before vaccination. If a vaccine dose has been administered during pregnancy, no intervention is needed. You can find more information about HPV vaccine and pregnancy in the ACIP recommendations at:

Last reviewed: October 13, 2023

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