What are CDC’s 2025–26 season COVID-19 vaccination recommendations for people age 6 months and older who are moderately or severely immunocompromised?

People who are moderately or severely immunocompromised are at increased risk for severe COVID-19 illness. ACIP and CDC recommend individual decision-making (also known as shared clinical decision-making) after a discussion with a healthcare professional (nurse, doctor, or pharmacist) for people age 6 months and older who are moderately or severely immunocompromised. They are recommended to receive at least 2 doses during the season. The CDC vaccination schedule for people with moderate or severe immunocompromise is available here: www.cdc.gov/covid/hcp/vaccine-considerations/immunocompromised.html.

The Infectious Diseases Society of America (IDSA) strongly recommends administration of age-appropriate 2025–2026 COVID-19 vaccinations to all adults and children with compromised immunity. They also recommend that household members and close contacts of immunocompromised people should be up to date with COVID-19 vaccination. See IDSA recommendations for full details: www.idsociety.org/Seasonal-RTI-Vaccinations-in-Immunocompromised-Patients/.