We have a 68-year-old patient who received PCV15, then received PPSV23 approximately 5 weeks later. She had not received PPSV23 previously. Is the PPSV23 dose valid, or does it need to be repeated?

What to do when doses of PCV15 and PPSV23 are given without the recommended minimum interval between them is not described in the ACIP pneumococcal recommendations. The CDC subject matter experts have provided the following guidance: in such a case, the dose given second does not need to be repeated. This is an exception to the usual procedure for a minimum interval violation (as described in ACIP’s “General Best Practices Guidelines for Immunization”). The recommended interval between the dose of PCV15 and PPSV23 is one year and the recommended minimum interval between doses is 8 weeks.