There is a vent in our combination refrigerator/freezer that brings in cold air from the freezer. Vaccines stored near this vent are colder to the touch. Could this be a problem?

Yes. Vaccines that are stored in the refrigerator portion of a household-style combination refrigerator/freezer should be moved away from the vent located in the refrigerator compartment. The cold air from the freezer is circulated into the refrigerator compartment to cool it, which can cause your vaccines to freeze. Inactivated vaccines must be kept between 2° and 8°C (between 36° and 46°F) and not frozen.