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  • Administering Vaccines
  • General Issues

We have a nurse in one of our clinics who gave separate doses of hepatitis A and hepatitis B vaccine in the gluteus. Are the doses of each antigen considered invalid? If so, can they be repeated at any time or do I need to count the spacing between doses from the date when the invalid dose was administered?

Although the gluteus muscle is not a recommended site for vaccination, in general, a dose given there can be considered valid. The exceptions to this general rule are hepatitis B and rabies vaccines, so the hepatitis B vaccine should not be counted in this situation. The hepatitis B vaccine can be repeated immediately. See the Advisory Committee on Immunization Practice’s (ACIP) “General Best Practices Guidelines for Immunization”, available at

Last reviewed: December 28, 2022

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