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  • Scheduling Vaccines
  • Cholera
  • Typhoid

Does live oral cholera vaccine need to be administered at an interval from other live oral or injectable vaccines?

In general, no. According to ACIP’s “General Best Practice Guidelines for Immunization”, concerns about spacing between doses of live vaccines not given at the same visit applies only to live injectable or intranasal vaccines. So, live oral cholera vaccine may be administered simultaneously with another vaccine, or at any interval before or after administration of another vaccine. There is one exception: ACIP recommends (based upon expert opinion) that live oral cholera vaccine should be administered at least 8 hours before the first dose of live oral Ty21a typhoid vaccine in order to minimize the risk that the oral cholera vaccine buffer might interfere with the enteric coating of the oral Ty21a vaccine.

Last reviewed: June 6, 2023

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