Can we administer PCV15 and PPSV23 vaccines to a person 65 years of age or older at the same visit? If not, what is the recommended interval between doses?

PCV15 and PPSV23 vaccines should not be given at the same visit. When administering PCV15 followed by PPSV23, give PCV15 first followed by PPSV23 one year later. Providers can consider waiting a minimum interval of 8 weeks to give PPSV23 to people with immunocompromising conditions, cochlear implant, or cerebrospinal fluid (CSF) leak.

If a patient inadvertently received PPSV23 before PCV15, a minimum interval of at least 1 year between doses is recommended and a shorter interval is not recommended.