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  • Combination Vaccines
  • HepA-HepB (Twinrix, GSK)

We heard that there is an alternative schedule for the Twinrix (HepA-HepB) that gives the patient protection sooner than the standard schedule does. Can you tell us more?

Twinrix is normally given as a 3-dose series on a schedule of 0, 1, and 6 months. However, if someone needs protection sooner (e.g., imminent foreign travel), you can give it as a 4-dose series at intervals of 0, 7, and 21–30 days, followed by a fourth (booster) dose at least 12 months after the first dose.

Last reviewed: July 15, 2023

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